Molecular Biology of Prostaglandin Receptor and L-Histidine Decarboxylase
نویسندگان
چکیده
منابع مشابه
Molecular biology of histidine decarboxylase and prostaglandin receptors
Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the...
متن کاملMOLECULAR MODELING AND NMR STUDY OF HISTDINIE AND ITS ANALOGUES AS , PYRIDOXAL 5 '-PHOSPHATE DEPENDENT HISTIDINE DECARBOXYLASE INHIBITORS
Molecular modeling analysis of charge density and heat of fornation by PM3 method as well as C, H NMR and 2D-NMR measurements of histidine (substrate) and some of its derivatives as histidine decarboxylase inhibitors were performed. It was established that the atom, usually nitrogen, which forms internal aldimine with pyridoxal5 -phosphate (PLP), (coenzyme), has negative and almost equal ...
متن کاملChapter 6 L - Histidine Decarboxylase A Marker of Histaminergic Neurons
The role of histamine (HA) as a neurotransmitter in the CNS, although proposed a decade ago (Schwartz, 1975), has been only progressively recognized (reviewed by Schwartz et al., 1980, 1982, 1984; Hough and Green, 1984). One of the key pieces of expenmental evidence has been the demonstration that synthesis of the amine in CNS depends on a specific enzyme, L-histidine decarboxylase (HDC) (Schwa...
متن کاملCrystallization and Subunit Structure of Histidine Decarboxylase
Histidine decarboxylase from Lactobacillus 30u has been crystallized in a variety of forms which together indicate a revised subunit structure for the native particle. Octahedral crystals of the wild type enzyme obtained at room temperature from ammonium sulfate solutions in microdiffusion cells belong to tetragonal space group 14122 with a = b = 222 A and c = 107.5 A. Trigonal and hexagonal pl...
متن کاملHistidine decarboxylase in Enterobacteriaceae revisited.
With a modification of Taylor's decarboxylation broth, histidine decarboxylase was detected in Enterobacter aerogenes, Morganella morganii, Raoultella ornithinolytica, and some strains of Citrobacter youngae and Raoultella planticola. This method provides a useful confirmatory test for identification of E. aerogenes strains.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1999
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.119.9_637